Familial Breast and Ovarian Cancer
نویسنده
چکیده
This text book is a timely publication and it gives a splendid overview of the genetics and management of familial breast and ovarian cancer. The book is edited by Professor Morrison and his colleagues and they have drawn together a national and an international list ofcontributors well respected in their fields. The book begins with a series of book chapters on molecular biology of these tumours.
منابع مشابه
Analysis of RAD51D in Ovarian Cancer Patients and Families with a History of Ovarian or Breast Cancer
Mutations in RAD51D have been associated with an increased risk of hereditary ovarian cancer and although they have been observed in the context of breast and ovarian cancer families, the association with breast cancer is unclear. The aim of this current study was to validate the reported association of RAD51D with ovarian cancer and assess for an association with breast cancer. We screened for...
متن کاملTowards Evidence-Based Management of Inherited Breast and Breast-Ovarian Cancer
Inherited breast-ovarian cancer was described in 1866. The underlying genetic defects in BRCA1/2 were demonstrated 128 years later. We now have 10 years of experience with genetic testing in BRCA kindreds. The majority of breast cancer kindreds (familial breast cancer) do not demonstrate ovarian cancer and are not associated with BRCA mutations. The effect of early diagnosis and treatment is mo...
متن کاملRAD51C is a susceptibility gene for ovarian cancer.
A homozygous mutation in the RAD51C gene was recently found to cause Fanconi anemia-like disorder. Furthermore, six heterozygous deleterious RAD51C mutations were detected in German breast and ovarian cancer families. We screened 277 Finnish familial breast or ovarian cancer patients for RAD51C and identified two recurrent deleterious mutations (c.93delG and c.837+1G>A). These mutations were fu...
متن کاملBRCA in breast cancer: ESMO clinical recommendations.
Familial susceptibility to breast cancer accounts for 25% of all breast cancer cases. In familial breast cancer, mutations in the BRCA1, BRCA2, CHEK2, TP53 and PTEN genes account for 5–10% of breast and ovarian cancer cases overall. The prevalence of BRCA1 or BRCA2 mutations varies considerably between ethnic groups and geographical areas. Populationspecific mutations have been described in Ice...
متن کاملDetection of P 53 gene mutations in exons 5 and 8 in patients of familial breast cancer with PCR-SSCP methode.
Background: Breast cancer is one of the most common cancer of women in the world. Although different genetic alteration has been reported in this malignancy, but P 53 gene mutations has more frequency. P 53 gene is one of the most important suppressor genes and it play a central role in breast cancer and detecting of mutations in this gene would be very helpful in understanding of genetic m...
متن کاملBreast Cancer 1 Gene
There are differences between the histopathology of breast cancers in carriers of BRCA1 and BRCA2 mutations. The findings can be interpreted as breast cancer due to BRCA1 has a different natural history from BRCA2 or apparently sporadic disease, which may have implications for screening and management. Mutations in the BRCA1 gene were implicated as causes of different types of cancers including...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Ulster Medical Journal
دوره 72 شماره
صفحات -
تاریخ انتشار 2003